Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs.
CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays …

Many drugs of abuse, including cannabinoids, opioids, alcohol and nicotine, can alter the
levels of endocannabinoids in the brain. Recent studies show that release of …

Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2) constitute a family of guanine nucleotide
exchange factors (GEFs). The main isoforms, p140-GRF1 and p135-GRF2, have 2 GEF …

We have previously reported that a single injection of an ultra-low dose of delta-9-
tetrahydrocannabinol (THC; the psychoactive ingredient of marijuana) protected the brain …

Ecstasy is a drug that is usually consumed by young people at the weekends and frequently,
in combination with cannabis. In the present study we have investigated the long-term …

Studies concerning drugs of abuse have made major contributions in defining the circuitry,
as well as cellular and molecular substrates that underlie certain behaviors. Opiate drugs for …

Cannabinoid CB1 receptors (CB1Rs) are expressed throughout the brain and mediate the
central effects of cannabinoids, including Δ9-tetrahydrocannabinol (THC), the main …

Background: Exposure to drugs of abuse induces neuroadaptations in critical nodes of the
so-called reward system s that are thought to mediate the transition from controlled drug use …

We investigated the role of the Ras/extracellular‐regulated kinase (ERK) pathway in the
development of tolerance to Δ9‐tetrahydrocannabinol (THC)‐induced reduction in …

The endocannabinoid system regulates various aspects of hepatic fibrosis; however,
nothing is known about its role in regulating cholangiocyte proliferation and function. We …