Sex-dependent differences have been consistently described in cannabinoid addiction
research. In particular, we recently reported that female Lister Hooded rats display greater …

Introduction: Repeated administration of abused drugs, including Δ9-tetrahydrocannabinol
(THC), induces the stable transcription factor ΔFosB in dopaminergic terminal field regions …

RasGRF is a family of guanine nucleotide exchange factors with dual specificity for both Ras
and Rac GTPases. In this study, using mouse brain extracts, we show that both RasGRF1 …

Transcriptional regulation is central to the long-term effects of drugs of abuse. Activation of
the extracellular signal-regulated kinase (ERK1/2) pathway underlies plasticity changes that …

The brain-specific Ras guanine nucleotide exchange factor RasGRF1 is a protein
harbouring a complex array of structural motifs. It contains a pleckstrin homology (PH1) …

Acetaminophen (also known as paracetamol) is a commonly used over-the-counter pain
medication, but recent evidence suggests that a single exposure or prenatal exposure may …

Derivatives of Cannabis sativa, such as marijuana and hashish, are the most widely
consumed illicit drug: almost half of all 18-year olds in the USA and in most European …

Summary The progression from Raphael Mechoulam's identification of Δ9‐
tetrahydrocannabinol as the primary psychoactive component of cannabis, through the …

IMPLICADOS EN LA REGULACIÓN ENTRE RECEPTORES OPIOIDE MU/CANNABINOIDE
CB1 Y GLUTAMATÉRGICO NMDA” ha sido realizado por Dña. Ana Vicente Sánchez en el …

Abstract Cannabidiol (CBD) and D9-tetrahydrocannabinol (D9-THC) are phytocannabinoids
produced by the plant Cannabis sativa which have both shown promising therapeutic value …