Importance Rotavirus infection is the global leading cause of diarrhea-associated morbidity
and mortality among children younger than 5 years. Objectives To examine the extent of …

Interaction with cellular glycans is a critical initial step in the pathogenesis of many infectious
agents. Technological advances in glycobiology have expanded the repertoire of studies …

Rotavirus vaccines have been introduced into over 95 countries globally and demonstrate
substantial impact in reducing diarrheal mortality and diarrheal hospitalizations in young …

Background Diarrheal diseases are the third leading cause of disease and death in children
younger than 5 years of age in Africa and were responsible for an estimated 30 million …

Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in
children aged less than 5 years in low-and middle-income countries where limited access to …

Identifying risk factors for impaired oral rotavirus vaccine (ORV) efficacy in low-income
countries may lead to improvements in vaccine design and delivery. In this prospective …

Safety, efficacy, and cost-effectiveness are paramount to vaccine development. Following
the isolation of rotavirus particles in 1969 and its evidence as an aetiology of severe …

Background Brazil introduced the monovalent rotavirus vaccine (Rotarix®) in 2006. This
study aimed to assess the epidemiology and genotype distribution of species-A rotavirus …

Background Rotavirus is a major contributor to child mortality. The effect of rotavirus vaccine
on diarrhoea mortality has been estimated in middle-income but not low-income settings …

Background. Diarrhea is the third leading cause of child death in Zambia. Up to one-third of
diarrhea cases resulting in hospitalization and/or death are caused by vaccine-preventable …