Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis

NES Tay, D Lehnherr, T Rovis - Chemical reviews, 2021 - ACS Publications
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives

K Peng, BB Liang, W Liu, ZW Mao - Coordination Chemistry Reviews, 2021 - Elsevier
Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …

Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives

C Ma, X Li, X Chen, X He, ST Zhang, YQ Jiang… - Organic …, 2023 - ACS Publications
Direct, economical, and green synthesis of deuterated α-amino phosphine oxides remains
an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven …

Selected organophosphorus compounds with biological activity. Applications in medicine

S Demkowicz, J Rachon, M Daśko, W Kozak - RSC advances, 2016 - pubs.rsc.org
The purpose of this article is to provide an overview of the latest applications of
organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs …

Recent Advances in the Construction of Phosphorus‐Substituted Heterocycles, 2009–2019

L Chen, XY Liu, YX Zou - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
Phosphorus‐substituted heterocycles represent an important class of organophosphorus
compounds, which not only widely exist in biologically active pharmaceuticals …

Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use

FH Ebetino, S Sun, P Cherian, S Roshandel… - Bone, 2022 - Elsevier
Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

The role of the phosphorus atom in drug design

JB Rodriguez, C Gallo‐Rodriguez - ChemMedChem, 2019 - Wiley Online Library
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Phosphine Oxides from a Medicinal Chemist's Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery

P Finkbeiner, JP Hehn, C Gnamm - Journal of Medicinal …, 2020 - ACS Publications
Phosphine oxides and related phosphorus-containing functional groups such as
phosphonates and phosphinates are established structural motifs that are still …

The Kabachnik–Fields reaction: Mechanism and synthetic use

G Keglevich, E Bálint - Molecules, 2012 - mdpi.com
The Kabachnik–Fields (phospha-Mannich) reaction involving the condensation of primary or
secondary amines, oxo compounds (aldehydes and ketones) and> P (O) H species …

Enantioselective Palladium‐Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides

Z Yang, J Wang - Angewandte Chemie, 2021 - Wiley Online Library
A Pd‐catalyzed hydrophosphinylation of alkyl and aryl‐oxyallenes with phosphine oxides
has been developed for the efficient and rapid construction of a family of chiral allylic …