Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …

Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility
group protein present in all cell types. HMGB1 plays multiple roles both inside and outside …

Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP
ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in …

Vascular calcification (VC) is linked to an increased risk of heart disease, stroke, and
atherosclerotic plaque rupture. It is a cell-active process regulated by vascular cells rather …

Extracellular vesicles (EVs), as part of the cellular secretome, have emerged as essential
cell–cell communication regulators in multiple physiological and pathological processes …

Aging shows a decline in overall physical function, and cellular senescence is the powerful
catalyst leading to aging. Considering that aging will be accompanied with the emergence of …

Extracellular vesicles (EV, exosomes and microvesicles-MV-) are 30–1000 nm particles
surrounded by a phospholipid bilayer membrane that are released from almost all cell types …

Exosomes are the self-packed nanoscale vesicles (nanovesicles) derived from late
endosomes and released from the cells to the extracellular milieu. Exosomal biogenesis is …