Despite being widely applied in drug development, existing in vitro 2D cell-based models
are not suitable to assess chronic mitochondrial toxicity. A novel in vitro assay system …

Urologic tissue engineering efforts have been largely focused on bladder and urethral defect
repair. The current surgical gold standard for treatment of poorly compliant pathological …

Background: Graphene has unique electrical, physical, and chemical properties that may
have great potential as a bioscaffold for neuronal regeneration after spinal cord injury …

Cell-seeded scaffolds are a common route of cell transplantation for bladder repair and
reconstruction. However, when cell suspensions are harvested, proteolytic enzymes often …

End stage kidney disease affects hundreds of thousands of patients in the United States.
The therapy of choice is kidney replacement, but availability of organs is limited, and …

Since the functional recovery of the reconstructed bladder is related to the bladder wall
contraction and existing therapies do not respond to this, tissue engineering could be worth …

Peripheral nerve injuries resulting from various traumatic events can cause mobility
problems and sensory impairment, jeopardizing patients' life quality and bringing serious …

Extracellular matrix (ECM) bioscaffolds have been widely studied to repair bladder tissue
defects; however, insufficient angiogenesis and weak mechanical strength limit their …

Background Preclinical validation of scaffold-based technologies in animal models of
urethral disease is desired to assess wound healing efficacy in scenarios that mimic the …

Neurons loss and axons degeneration after spinal cord injury (SCI) gradually give rise to
result in functional motor and sensory impairment. A bridging biomaterial scaffold that allows …