The chicken anemia virus (CAV) protein Apoptin is a small, 13.6-kDa protein that has the
intriguing activity of inducing G2/M arrest and apoptosis specifically in cancer cells by a …

Mitosis is controlled by a complex series of signaling pathways but mitotic control following
DNA damage remains poorly understood. Effective DNA damage sensing and repair is …

Viruses frequently exploit host cell cycle machineries for their own benefit, often by targeting
'master switches' of cell cycle regulation. By doing so, they achieve maximum effect from …

Cancer development is often connected to impaired DNA repair and DNA damage signaling
pathways. The presence of DNA damage in cells activates DNA damage response, which is …

Microcephalin (MCPH1), the first gene identified as causative for primary recessive
autosomal microcephaly, is aberrantly expressed in autism-like disorders and human …

During eukaryotic DNA damage response (DDR), one of the earliest events is the
phosphorylation of the C-terminal SQ motif of histone H2AX (H2A in yeasts). In human cells …

Mammalian oocytes are particularly susceptible to accumulating DNA damage. However,
unlike mitotic cells in which DNA damage induces G2 arrest by activating the ATM-Chk1/2 …

The first step in V (D) J recombination is the formation of specific DNA double-strand breaks
(DSBs) by the RAG1 and RAG2 proteins, which form the RAG recombinase. DSBs activate a …

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets
substrates for degradation to promote mitotic progression. Here, we show that the DNA …

In order to maintain genetic integrity, cells are equipped with cell cycle checkpoints that
detect DNA damage, orchestrate repair, and if necessary, eliminate severely damaged cells …