MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner
C Strauss, T Halevy, M Macarov, L Argaman… - DNA repair, 2011 - Elsevier
The cellular response to DNA damage is essential for maintenance of genomic stability.
MDC1 is a key member of the DNA damage response. It is an adaptor protein that binds and …
MDC1 is a key member of the DNA damage response. It is an adaptor protein that binds and …
[图书][B] The anaphase promoting complex/cyclosome (APC/C): a versatile E3 ubiquitin ligase
NL Curtis, VM Bolanos-Garcia - 2019 - Springer
In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase
Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging …
Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging …
CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage
Cells engage sophisticated programs of DNA damage response (DDR) and repair to guard
against genetic mutations. Although there is significant knowledge concerning DDR in …
against genetic mutations. Although there is significant knowledge concerning DDR in …
An easy-to-use genotoxicity assay using EGFP-MDC1-expressing human cells
S Matsuda, R Matsuda, Y Matsuda… - Genes and …, 2014 - jstage.jst.go.jp
Histone H2AX phosphorylated at Ser139 (g-H2AX) is a useful biomarker for DNA double-
strand breaks. However, g-H2AX detection has methodological disadvantages such as the …
strand breaks. However, g-H2AX detection has methodological disadvantages such as the …
[PDF][PDF] NFBD1/MDC1: DNA damage response, cell cycle regulation and carcinogenesis
T Ozaki, Y Bu, H Nagase - Cancer Research Frontiers, 2015 - pdfs.semanticscholar.org
The cellular genome is constantly exposed to the endogenous as well as the exogenous
DNA damages. Thus, the proper cellular response to DNA damage plays a critical role to …
DNA damages. Thus, the proper cellular response to DNA damage plays a critical role to …
[HTML][HTML] Protein structure
H Mouse - 2004 - iiab.me
SLITRK1 contains 2 horseshoe shaped leucine rich repeat domains (LRRs) in its
extracellular domain which are vital to its function.[4] The LRRs have 6 modules each and …
extracellular domain which are vital to its function.[4] The LRRs have 6 modules each and …
Towards the Treatment of Secondarily Mutated Leukemia
ERFY Chu - 2022 - hammer.purdue.edu
Acute myeloid leukemia (AML) is a devastating cancer with an overall 5-year survival rate of
approximately 30%, despite efforts to develop therapeutics to combat this disease. AML is …
approximately 30%, despite efforts to develop therapeutics to combat this disease. AML is …
[PDF][PDF] The Functional and Molecular Characterisation of the Novel DNA Damage Repair Protein Bod1L.
AM Davies - 2015 - discovery.dundee.ac.uk
DNA damage induces MDC1 recruitment and establishes a signalling platform that mediates
the DNA damage response (DDR). I show that Bod1L plays a central role in DDR by …
the DNA damage response (DDR). I show that Bod1L plays a central role in DDR by …