Focal seizure propagation is classically thought to be spatially contiguous. However,
distribution of seizures through a large-scale epileptic network has been theorized. Here, we …

In this photo essay, we present a sampling of technologies from laboratories at the forefront
of whole-brain clearing and imaging for high-resolution analysis of cell populations and …

The BRAIN Initiative arose from a grand challenge to “accelerate the development and
application of new technologies that will enable researchers to produce dynamic pictures of …

Alcohol and drug use can dysregulate neural circuit function to produce a wide range of
neuropsychiatric disorders, including addiction. To understand the neural circuit …

Current drug treatments for epilepsy attempt to broadly restrict excitability to mask a
symptom, seizures, with little regard for the heterogeneous mechanisms that underlie …

Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …

Research in neuroscience and neuroengineering has attracted tremendous interest in the
past decades. However, the complexity of the brain tissue, in terms of its structural, chemical …

Voltage imaging enables monitoring neural activity at sub-millisecond and sub-cellular
scale, unlocking the study of subthreshold activity, synchrony, and network dynamics with …

Optical methods that rely on fluorescence for mapping changes in neuronal membrane
potential in the brains of awake animals provide a powerful way to interrogate the activity of …

Emotional responses arise from limbic circuits including the hippocampus and amygdala. In
the human brain, beta-frequency communication between these structures correlates with …