[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry
F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …
treatment-related effects were carefully reported and used as a basis to calculate safety …
[HTML][HTML] Mechanisms of action of fluvoxamine for COVID-19: a historical review
Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …
[HTML][HTML] Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
Hydrogen-bond donors in drug design
PW Kenny - Journal of Medicinal Chemistry, 2022 - ACS Publications
Hydrogen-bond donors are seen to cause more problems for drug designers than hydrogen-
bond acceptors. Most of the polarity in drug-like compounds comes from hydrogen-bond …
bond acceptors. Most of the polarity in drug-like compounds comes from hydrogen-bond …
[HTML][HTML] Adverse effects following COVID-19 vaccination in Iran
E Babaee, A Amirkafi, A Tehrani-Banihashemi… - BMC Infectious …, 2022 - Springer
Background Vaccination is a key intervention to prevent COVID-19. Many vaccines are
administered globally, yet there is not much evidence regarding their safety and adverse …
administered globally, yet there is not much evidence regarding their safety and adverse …
[HTML][HTML] Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Antivirals that specifically target SARS-CoV-2 are needed to control the COVID-19
pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an …
pandemic. The main protease (Mpro) is essential for SARS-CoV-2 replication and is an …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …
equipped for future pandemics. While unprecedented strides have been made developing …
Efficacy of repurposed antiviral drugs: lessons from COVID-19
MA Martinez - Drug Discovery Today, 2022 - Elsevier
The clinical, social, and economic impacts of the coronavirus disease 2019 (COVID-19)
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
pandemic, originated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[HTML][HTML] Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients
S Veleri - Experimental brain research, 2022 - Springer
The devastating COVID-19 pandemic is caused by the SARS-CoV-2 virus. It primarily affects
the lung and induces acute respiratory distress leading to a decrease in oxygen supply to …
the lung and induces acute respiratory distress leading to a decrease in oxygen supply to …