[HTML][HTML] HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases

E Eusebio-Ponce, E Anguita… - Revista Española de …, 2019 - ncbi.nlm.nih.gov
ABSTRACT The Human T-Lymphotropic Virus type 1 (HTLV-1) affects up to 10 million
people worldwide. It is directly associated to one of the most aggressive T cell malignancies …

Cytokine networks dysregulation during HTLV-1 infection and associated diseases

N Futsch, G Prates, R Mahieux, J Casseb, H Dutartre - Viruses, 2018 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

Quantitative fragmentomics allow affinity mapping of interactomes

G Gogl, B Zambo, C Kostmann, A Cousido-Siah… - nature …, 2022 - nature.com
Human protein networks have been widely explored but most binding affinities remain
unknown, hindering quantitative interactome-function studies. Yet interactomes rely on …

HTLV-1 extracellular vesicles promote cell-to-cell contact

DO Pinto, C DeMarino, ML Pleet, M Cowen… - Frontiers in …, 2019 - frontiersin.org
Human T-cell leukemia virus-1 (HTLV-1) is a neglected and incurable retrovirus estimated to
infect 5 to 10 million worldwide. Specific indigenous Australian populations report infection …

Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies

J Chen, M Foroozesh, Z Qin - Oncogenesis, 2019 - nature.com
Human endogenous retroviruses (HERVs), viral-associated sequences, are normal
components of the human genome and account for 8–9% of our genome. These original …

NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years

CS Santana, FO Andrade, GCS da Silva… - Frontiers in …, 2023 - frontiersin.org
Introduction The Human T-lymphotropic virus type 1 (HTLV-1) was the first described human
retrovirus. It is currently estimated that around 5 to 10 million people worldwide are infected …

HTLV-1 is also a sexually transmitted infection

M Martel, E Gotuzzo - Frontiers in Public Health, 2022 - frontiersin.org
HTLV-1 is a retrovirus which causes diverse diseases in 10% of its infected population,
significantly worsening their quality of life and mortality rate. Even though it is globally …

Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles

A Malyshkina, W Bayer, P Podschwadt, L Otto… - PLoS …, 2023 - journals.plos.org
Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic
condition. However, eliminating the virus remains an elusive therapy goal. For several …

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

P Miyazato, M Matsuo, BJY Tan, M Tokunaga… - Retrovirology, 2019 - Springer
Background Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with
human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated …