Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …

Ovarian cancer is responsible for 4% of deaths from cancer in women. Treatment comprises
a combination of surgery and chemotherapy, but patients typically experience disease …

Plasmodium falciparum is the causative agent of the most burdensome form of human
malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced …

Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …

A striking link exists between advanced age and increased incidence of cancer. Here I
review how several of the age-related molecular and physiological changes might act in …

Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli.
Human cells develop a senescence-associated secretory phenotype (SASP), which …

DNA damage frequently triggers death by apoptosis. The irreversible decision to die can be
facilitated or forestalled through integration of a wide variety of stimuli from within and …

Many human tumours show centrosome aberrations, indicating an underlying deregulation
of centrosome structure, duplication or segregation. Centrosomes organize microtubule …

The past decade has seen great strides in our understanding of the genetic basis of human
disease. Arguably, the most profound impact has been in the area of cancer genetics, where …

Cancer genetics has for many years focused on mutational events that have their primary
effect within the cancer cell. Recently that focus has widened, with evidence of the …