Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

The new-generation hormonal agent enzalutamide has been approved for the treatment of
metastatic castration-resistant prostate cancer (CRPC), in both post-and predocetaxel …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate
eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the …

Breast and prostate cancers are malignancies in which steroid hormones drive cellular
proliferation. Over the past century, this understanding has led to successful treatment …

Prostate cancer (PCa) is recognized as a disease possessing not only great variation in its
geographic and racial distribution but also tremendous variation in its potential to cause …

Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots
of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric …