The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity
HA Heck, M Casanova - Regulatory Toxicology and Pharmacology, 2004 - Elsevier
Formaldehyde is a naturally occurring biological compound that is present in tissues, cells,
and bodily fluids. It is also a potent nasal irritant, a cytotoxicant at high doses, and a nasal …
and bodily fluids. It is also a potent nasal irritant, a cytotoxicant at high doses, and a nasal …
Inhaled formaldehyde: exposure estimation, hazard characterization, and exposure-response analysis
RG Liteplo, ME Meek - Journal of Toxicology and Environmental …, 2003 - Taylor & Francis
Formaldehyde has been assessed as a Priority Substance under the Canadian
Environmental Protection Act. Probabilistic estimates of exposure of the general population …
Environmental Protection Act. Probabilistic estimates of exposure of the general population …
DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde
M Casanova, KT Morgan, EA Gross, OR Moss… - … and applied toxicology, 1994 - Elsevier
DNA-Protein Cross-links and Cell Replication at Specific Sites in the Nose of F344 Rats
Exposed Subchronically to Formaldehyde. Casanova, M., Morgan, KT, Gross, EA, Moss, OR …
Exposed Subchronically to Formaldehyde. Casanova, M., Morgan, KT, Gross, EA, Moss, OR …
A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments
BE Butterworth, RB Conolly, KT Morgan - Cancer letters, 1995 - Elsevier
The current standard approach for assessing carcinogenic potential is to conduct a near
lifetime rodent pathology study with the high dose set to the maximum tolerated dose (MTD) …
lifetime rodent pathology study with the high dose set to the maximum tolerated dose (MTD) …
Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS Human Framework for the Analysis of a cancer mode of …
D McGregor, H Bolt, V Cogliano… - Critical reviews in …, 2006 - Taylor & Francis
Formaldehyde and glutaraldehyde cause toxicity to the nasal epithelium of rats and mice
upon inhalation. In addition, formaldehyde above certain concentrations induces dose …
upon inhalation. In addition, formaldehyde above certain concentrations induces dose …
Pharmacodynamics of formaldehyde: applications of a model for the arrest of DNA replication by DNA–protein cross-links
HA Heck, M Casanova - Toxicology and applied pharmacology, 1999 - Elsevier
A variety of evidence suggests that formaldehyde (HCHO)-induced DNA–protein cross-links
(DPX) are genotoxic as a result of their ability to arrest DNA replication. Although DPX can …
(DPX) are genotoxic as a result of their ability to arrest DNA replication. Although DPX can …
Comparison of inhaled formaldehyde dosimetry predictions with DNA–protein cross-link measurements in the rat nasal passages
EAC Hubal, PM Schlosser, RB Conolly… - Toxicology and applied …, 1997 - Elsevier
Kimbell and coworkers (Toxicol. Appl. Pharmacol. 121,253–263, 1993) developed a
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
[HTML][HTML] Formaldehyde
IARC Working Group on the Evaluation of … - Wood Dust and …, 1995 - ncbi.nlm.nih.gov
This substance was considered by previous working groups, in October 1981 (IARC, 1982)
and March 1987 (IARC, 1987a). Since that time, new data have become available, and …
and March 1987 (IARC, 1987a). Since that time, new data have become available, and …
Biological effect markers for exposure to carcinogenic compound and their relevance for risk assessment
JHM Delft, RA Baan, L Roza - Critical reviews in toxicology, 1998 - Taylor & Francis
In this review data are summarized on biomarkers that are used for biological effect
monitoring of human populations exposed to genotoxic carcinogens. The biomarkers are …
monitoring of human populations exposed to genotoxic carcinogens. The biomarkers are …
Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
RB Conolly, PD Lilly, JS Kimbell - Environmental health perspectives, 2000 - JSTOR
Formaldehyde inhalation causes formation of DNA-protein cross-links (DPX) in the nasal
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …