The microbiome of oral squamous cell carcinomas: a functional perspective

NN Al-Hebshi, WS Borgnakke, NW Johnson - Current Oral Health Reports, 2019 - Springer
Abstract Purpose of Review This decade has witnessed increasing interest in the potential
role of the oral microbiome in head and neck cancers, particularly oral squamous cell …

Role of angiopoietins in development of cancer and neoplasia associated with viral infection

X Yu, F Ye - Cells, 2020 - mdpi.com
Angiopoietin/tyrosine protein kinase receptor Tie-2 signaling in endothelial cells plays an
essential role in angiogenesis and wound healing. Angiopoietin-1 (Ang-1) is crucial for …

NAT10-dependent N4‐acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation

Q Yan, J Zhou, Z Wang, X Ding, X Ma, W Li… - Nature …, 2023 - nature.com
Abstract N-acetyltransferase 10 (NAT10) is an N 4‐acetylcytidine (ac4C) writer that catalyzes
RNA acetylation at cytidine N4 position on tRNAs, rRNAs and mRNAs. Recently, NAT10 and …

Shiftless restricts viral gene expression and influences RNA granule formation during Kaposi's sarcoma-associated herpesvirus lytic replication

W Rodriguez, T Mehrmann, D Hatfield… - Journal of …, 2022 - Am Soc Microbiol
Herpesviral infection reflects thousands of years of coevolution and the constant struggle
between virus and host for control of cellular gene expression. During Kaposi's sarcoma …

KSHV hijacks FoxO1 to promote cell proliferation and cellular transformation by antagonizing oxidative stress

T Li, SJ Gao - Journal of medical virology, 2023 - Wiley Online Library
Reactive oxygen species (ROS) are a group of a highly short‐lived molecules that control
diverse behaviors of cells. Normal cells maintain ROS balance to ensure their functions …

Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV

M van Gent, A Reich, SE Velu, MU Gack - PLoS Biology, 2021 - journals.plos.org
The oncogenic human herpesviruses Epstein–Barr virus (EBV) and Kaposi's sarcoma-
associated herpesvirus (KSHV) are the causative agents of multiple malignancies. A …

METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle

X Zhang, W Meng, J Feng, X Gao, C Qin, P Feng… - Cell Death & …, 2023 - nature.com
Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) consists of latent and lytic
replication phases, both of which are important for the development of KSHV-related …

m6A Regulates the Stability of Cellular Transcripts Required for Efficient KSHV Lytic Replication

O Manners, B Baquero-Perez, TJ Mottram, ID Yonchev… - Viruses, 2023 - mdpi.com
The epitranscriptomic modification N 6-methyladenosine (m6A) is a ubiquitous feature of the
mammalian transcriptome. It modulates mRNA fate and dynamics to exert regulatory control …

Pseudomonas aeruginosa stimulates inflammation and enhances Kaposi's sarcoma herpesvirus-induced cell proliferation and cellular transformation through both …

A Markazi, PM Bracci, M McGrath, SJ Gao - MBio, 2020 - Am Soc Microbiol
Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi's
sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi's sarcoma …

RUNX3 inhibits KSHV lytic replication by binding to the viral genome and repressing transcription

P Ren, D Niu, S Chang, L Yu, J Ren, Y Ma… - Journal of …, 2024 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma herpesvirus family,
which can cause human malignancies including Kaposi sarcoma, primary effusion …