Precision medicine (PM) is personalized medicine that can develop targeted medical
therapies for the individual patient, in which “omics” sciences lead to an integration of data …

There are lasting concerns on calvarial development because cranium not only
accommodates the growing brain, but also safeguards it from exogenous strikes. In the past …

Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2
gene, affecting bone and teeth development. Previous studies focused on mutations in the …

The ubiquitin‐proteasome system (UPS) plays an important role in maintaining cellular
homeostasis by degrading a multitude of key regulatory proteins. FBXW11, also known as b …

Purpose Runx2 and osteocalcin have pivotal roles in bone homeostasis. Polymorphism of
these two genes could alter the function of osteoblasts and consequently bone mineral …

Currently, over 500 rare genetic bone disorders are identified. These diseases are often
accompanied by dental abnormalities, which are sometimes the first clue for an early …

Objective Skeletal dysplasia (SD) comprises more than 450 separate disorders. We
hypothesized that their dental features would be distinctive and investigated the tooth …

Many systemic diseases have orofacial manifestations with radiographic findings. In this
article, a range of systemic diseases with radiographic orofacial manifestations are …

Background Cleidocranial dysplasia (CCD) is a rare and underdiagnosed congenital
disorder in dentistry. The purpose of this study was to illustrate and quantify the maxillofacial …

Tooth eruption is a tightly regulated phenomenon involving teeth cells and the surrounding
alveolus. Combinatorial expression of RANKL in osteoblasts and RANK on osteoclast …