The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Patients with Parkinson's disease present with signs and symptoms of dysregulation of the
peripheral autonomic nervous system that can even precede motor deficits. This …

The traditional two-dimensional (2D) cell culture methods have a long history of mimicking in
vivo cell growth. However, these methods cannot fully represent physiological conditions …

There is an urgent need for predictive in vitro models to improve disease modeling and drug
target identification and validation, especially for neurological disorders. Cerebral …

Osteochondral (OC) defects are debilitating joint injuries characterized by the loss of full
thickness articular cartilage along with the underlying calcified cartilage through to the …

Microphysiological systems (MPS) designed to study the complexities of the peripheral and
central nervous systems have made marked improvements over the years and have allowed …

The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …

The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical
demand for fundamental neuroscience studies and therapeutic evaluation. Despite …

Neuronal cultures are a prominent experimental tool to understand complex functional
organization in neuronal assemblies. However, neurons grown on flat surfaces exhibit a …