Autophagy is a conserved bulk degradation and recycling process that plays important roles
in multiple biological functions, including inflammatory responses. As an important …

Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

Microglial activation-induced neuroinflammation is closely associated with the development
of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological …

Objectives and design Chlorogenic acid, which belongs to the polyphenols, is an anti-
oxidant and anti-obesity agent. In this study, we investigated the role of chlorogenic acid in …

Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of
proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and …

Renal inflammation and fibrosis are the common pathways leading to progressive chronic
kidney disease (CKD). We previously identified hematopoietic cell kinase (HCK) as …

Neuroinflammation caused by microglial activation and consequent neurological impairment
are prominent features of diabetes-associated cognitive impairment (DACI). Microglial …

Microglia have multiple functions in regulating homeostasis in the central nervous system
(CNS), and microglial inflammation is thought to play a role in the etiology of the …

Microglia are innate immune cells in the central nervous system (CNS), that supplies
neurons with key factors for executing autophagosomal/lysosomal functions …

Gut microbiota play a role in regulating mental disorders, but the mechanism by which gut
microbiota regulate brain function remains unclear. Gram negative and positive gut bacteria …