Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface
of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor …

Dysregulated epigenetic modifications dynamically drive the abnormal transcription process
to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance …

Simple Summary Breast cancer is the most prevalent malignancy in women. With the
improvement of medical treatment, breast cancer has become one of the solid tumors with …

Immunotherapy has gradually emerged as the most promising anticancer therapy. In
addition to conventional anti-PD-1/PD-L1 therapy, anti-CTLA-4 therapy, CAR-T therapy, etc …

Immune reactions are involved in both tumour and normal tissue in response to therapy.
Elevated secretion of certain chemokines, exosomes and cytokines triggers inflammation …

Acute respiratory distress syndrome (ARDS) has been a life threat for patients in ICUs. Vast
efforts have been devoted, while no medication has proved viable, which may be ascribed to …

Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers,
modulating chromatin structure and gene expression, which plays an important role in cell …

Background Distant metastasis remains the leading cause of treatment failure in patients
with nasopharyngeal carcinoma (NPC), making it critical to identify efficient therapeutic …

Abstract The programmed‐death‐ligand‐1 (PD‐L1) is an immune‐modulating molecule that
is constitutively expressed on various immune cells, different epithelial cells and a multitude …

Inducing cell death while simultaneously enhancing antitumor immune responses is a
promising therapeutic approach for multiple cancers. Celastrol (Cel) and 7-ethyl-10 …