Sulfur in dynamic covalent chemistry

AG Orrillo, RLE Furlan - Angewandte Chemie, 2022 - Wiley Online Library
Sulfur has been important in dynamic covalent chemistry (DCC) since the beginning of the
field. Mainly as part of disulfides and thioesters, dynamic sulfur‐based bonds (DSBs) have a …

[HTML][HTML] The protometabolic nature of prebiotic chemistry

N Nogal, M Sanz-Sánchez, S Vela-Gallego… - Chemical Society …, 2023 - pubs.rsc.org
The field of prebiotic chemistry has been dedicated over decades to finding abiotic routes
towards the molecular components of life. There is nowadays a handful of prebiotically …

Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

S Kim, JB Chae, D Kim, CW Park, Y Sim… - Journal of the …, 2023 - ACS Publications
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …

A Peptide-Based Oscillator

D Dev, N Wagner, B Pramanik, B Sharma… - Journal of the …, 2023 - ACS Publications
Living organisms are replete with rhythmic and oscillatory behavior at all levels, to the extent
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …

Enantioselective Self-Replicators

S Yang, Y Geiger, M Geerts, MJ Eleveld… - Journal of the …, 2023 - ACS Publications
Self-replicating molecules provide a simple approach for investigating fundamental
processes in scenarios of the emergence of life. Although homochirality is an important …

[HTML][HTML] On the chemical origin of biological cognition

R Pascal, A Pross - Life, 2022 - mdpi.com
One of life's most striking characteristics is its mental dimension, one whose very existence
within a material system has long been a deep scientific mystery. Given the current scientific …

Assessment of stoichiometric autocatalysis across element groups

Z Peng, ZR Adam, AC Fahrenbach… - Journal of the American …, 2023 - ACS Publications
Autocatalysis has been proposed to play critical roles during abiogenesis. These proposals
are at odds with a limited number of known examples of abiotic (and, in particular, inorganic) …

Adaptive Supramolecular Networks: Emergent Sensing from Complex Systems

AJ Selinger, F Hof - Angewandte Chemie, 2023 - Wiley Online Library
Molecular differentiation by supramolecular sensors is typically achieved through sensor
arrays, relying on the pattern recognition responses of large panels of isolated sensing …

Binding of precursors to replicator assemblies can improve replication fidelity and mediate error correction

O Markovitch, J Wu, S Otto - Angewandte Chemie International …, 2024 - Wiley Online Library
Copying information is vital for life's propagation. Current life forms maintain a low error rate
in replication, using complex machinery to prevent and correct errors. However, primitive life …

Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems

É Bartus, A Tököli, B Mag, Á Bajcsi… - Journal of the …, 2023 - ACS Publications
The concept of chemically evolvable replicators is central to abiogenesis. Chemical
evolvability requires three essential components: energy-harvesting mechanisms for …