Sulfur in dynamic covalent chemistry
AG Orrillo, RLE Furlan - Angewandte Chemie, 2022 - Wiley Online Library
Sulfur has been important in dynamic covalent chemistry (DCC) since the beginning of the
field. Mainly as part of disulfides and thioesters, dynamic sulfur‐based bonds (DSBs) have a …
field. Mainly as part of disulfides and thioesters, dynamic sulfur‐based bonds (DSBs) have a …
[HTML][HTML] The protometabolic nature of prebiotic chemistry
N Nogal, M Sanz-Sánchez, S Vela-Gallego… - Chemical Society …, 2023 - pubs.rsc.org
The field of prebiotic chemistry has been dedicated over decades to finding abiotic routes
towards the molecular components of life. There is nowadays a handful of prebiotically …
towards the molecular components of life. There is nowadays a handful of prebiotically …
Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells
S Kim, JB Chae, D Kim, CW Park, Y Sim… - Journal of the …, 2023 - ACS Publications
Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …
strategy for various age-related diseases. Most senolytics target antiapoptotic proteins …
A Peptide-Based Oscillator
Living organisms are replete with rhythmic and oscillatory behavior at all levels, to the extent
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …
that oscillations have been termed as a defining attribute of life. Recent studies of synthetic …
Enantioselective Self-Replicators
Self-replicating molecules provide a simple approach for investigating fundamental
processes in scenarios of the emergence of life. Although homochirality is an important …
processes in scenarios of the emergence of life. Although homochirality is an important …
[HTML][HTML] On the chemical origin of biological cognition
One of life's most striking characteristics is its mental dimension, one whose very existence
within a material system has long been a deep scientific mystery. Given the current scientific …
within a material system has long been a deep scientific mystery. Given the current scientific …
Assessment of stoichiometric autocatalysis across element groups
Autocatalysis has been proposed to play critical roles during abiogenesis. These proposals
are at odds with a limited number of known examples of abiotic (and, in particular, inorganic) …
are at odds with a limited number of known examples of abiotic (and, in particular, inorganic) …
Adaptive Supramolecular Networks: Emergent Sensing from Complex Systems
AJ Selinger, F Hof - Angewandte Chemie, 2023 - Wiley Online Library
Molecular differentiation by supramolecular sensors is typically achieved through sensor
arrays, relying on the pattern recognition responses of large panels of isolated sensing …
arrays, relying on the pattern recognition responses of large panels of isolated sensing …
Binding of precursors to replicator assemblies can improve replication fidelity and mediate error correction
Copying information is vital for life's propagation. Current life forms maintain a low error rate
in replication, using complex machinery to prevent and correct errors. However, primitive life …
in replication, using complex machinery to prevent and correct errors. However, primitive life …
Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems
É Bartus, A Tököli, B Mag, Á Bajcsi… - Journal of the …, 2023 - ACS Publications
The concept of chemically evolvable replicators is central to abiogenesis. Chemical
evolvability requires three essential components: energy-harvesting mechanisms for …
evolvability requires three essential components: energy-harvesting mechanisms for …