Inspired by life assembly systems, the construction of transient assembly systems with
spatiotemporal control is crucial for developing intelligent materials. A widely adopted …

Darwinian evolution of synthetic self-replicating entities is likely to have an important role in
the emergence of life from inanimate chemical matter. Darwinian evolution of self-replicators …

Present-day life is amazingly diverse and complex owing to Darwinian evolution. Despite
the simplicity of the principle of Darwinian evolution, the process and its outcomes are …

To further explore the origins of Life, we consider three self-replicating chemical models. In
general, models of the origin of Life include molecular components that can self-replicate …

This study explores the catalytic potential of short peptides containing Cys, a potent
nucleophile, able to hydrolyze a variety of ester substrates, including p-NPP and ATP, while …

This thesis describes our attempts to develop new self-replicating systems and to install
functions that are as lifelike as possible. The introduction (chapter 1) opens with a general …

At the earliest development of prebiotic chemistry, bacterial cells were primarily viewed as
“bags of molecules.” This longstanding viewpoint shaped and biased early research about …

An E. coli cell contains~ 2500 different chemicals which combine into an ordered
biochemical reaction network out of which emerges a living system. A chemist taking 2500 …

Self-replicating molecules provide a simple approach for investigating fundamental
processes in scenarios of the emergence of life. Although homochirality is an important …

Carbohydrates are some of the most important biopolymers, along with proteins and
polynucleotides. In nature, glycans are used for energy storage, as structural fibers, and for …