Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Cancer represents an evolutionary process through which growing malignant populations
genetically diversify, leading to tumour progression, relapse and resistance to therapy. In …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

Understanding the evolutionary and ecological roles of'non-genetic'inheritance (NGI) is
daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights …

Epigenetic inheritance of gene expression states enables a single genome to maintain
distinct cellular identities. How histone modifications contribute to this process remains …

The epigenome, including DNA methylation, is stably propagated during mitotic division.
However, single-cell clonal expansion produces heterogeneous methylomes, thus raising …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …

DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular
mechanisms connecting DNA methylation patterns and enzyme activity remain elusive …

Surface epithelia provide a critical barrier to the outside world. Upon a barrier breach,
resident epithelial and immune cells coordinate efforts to control infections and heal tissue …

The cellular machinery that regulates gene expression can be self-propagated across cell
division cycles and even generations. This renders gene expression states and their …