Recommendations for the collection and annotation of biosamples for analysis of biomarkers in neurofibromatosis and schwannomatosis clinical trials
RT Sundby, SD Rhodes, E Komlodi-Pasztor… - Clinical …, 2024 - journals.sagepub.com
Introduction Neurofibromatosis 1 and schwannomatosis are characterized by potential
lifelong morbidity and life-threatening complications. To date, however, diagnostic and …
lifelong morbidity and life-threatening complications. To date, however, diagnostic and …
Phase I trial of ganitumab plus dasatinib to cotarget the insulin-like growth factor 1 receptor and src family kinase YES in rhabdomyosarcoma
S Akshintala, RT Sundby, D Bernstein, JW Glod… - Clinical cancer …, 2023 - AACR
Purpose: Antibodies against insulin-like growth factor (IGF) type 1 receptor have shown
meaningful but transient tumor responses in patients with rhabdomyosarcoma (RMS). The …
meaningful but transient tumor responses in patients with rhabdomyosarcoma (RMS). The …
Contemporary Approach to Neurofibromatosis Type 1–Associated Malignant Peripheral Nerve Sheath Tumors
Most malignant peripheral nerve sheath tumors (MPNSTs) are clinically aggressive high-
grade sarcomas, arising in individuals with neurofibromatosis type 1 (NF1) at a significantly …
grade sarcomas, arising in individuals with neurofibromatosis type 1 (NF1) at a significantly …
MiR-146a-5p enrichment in small-extracellular vesicles of relapsed pediatric ALCL patients promotes macrophages infiltration and differentiation
A Garbin, G Contarini, CC Damanti, A Tosato… - Biochemical …, 2023 - Elsevier
Anaplastic large cell lymphoma (ALCL) is a CD30-positive lymphoma accounting for 20% of
all pediatric T-cell lymphomas. Current first line treatment can cure most of ALCL patients but …
all pediatric T-cell lymphomas. Current first line treatment can cure most of ALCL patients but …
Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics
Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors
(PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we …
(PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we …
[HTML][HTML] Circulating Cell-Free Tumor Deoxyribonucleic Acid Analysis as a Tool for the Diagnosis and Monitoring of Pediatric Solid Tumors
L Zaninović, M Bašković, AK Bojanac… - Turkish archives of …, 2023 - ncbi.nlm.nih.gov
The utility of cell-free tumor deoxyribonucleic acid analysis is currently being evaluated in a
wide range of clinical studies. The validity of cell-free tumor deoxyribonucleic acid analysis …
wide range of clinical studies. The validity of cell-free tumor deoxyribonucleic acid analysis …
Cancer incidence and surveillance strategies in individuals with RASopathies
RASopathies are a set of clinical syndromes that have molecular and clinical overlap.
Genetically, these syndromes are defined by germline pathogenic variants in RAS/MAPK …
Genetically, these syndromes are defined by germline pathogenic variants in RAS/MAPK …