Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Diabetes mellitus is a major public health problem, affecting about 10% of the population.
Pharmacotherapy aims to protect against microvascular complications, including blindness …

In the past three decades, total fat and saturated fat intake as a percentage of total calories
has continuously decreased in Western diets, while the intake of omega-6 fatty acid …

Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

As our understanding of the endocannabinoids improves, so does the awareness of their
complexity. During pathological states, the levels of these mediators in tissues change, and …

Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …

Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in
various therapeutic applications from pain to epilepsy, but its psychotropic effect has …

With their ever-growing prevalence, obesity and diabetes represent major health threats of
our society. Based on estimations by the World Health Organization, approximately 300 …