The diverse role of the raphe 5-HTergic systems in epilepsy
H Cheng, C Gao, Q Lou, Z Chen, Y Wang - Acta Pharmacologica Sinica, 2022 - nature.com
The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic (5-HTergic) neurons in the
brain and are widely acknowledged to participate in the modulation of neural …
brain and are widely acknowledged to participate in the modulation of neural …
Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear …
Decrease of γ-aminobutyric acid (GABA)-mediated neurotransmission in the dorsomedial
hypothalamus (DMH) evokes instinctive fear-like responses. The aim of the present study …
hypothalamus (DMH) evokes instinctive fear-like responses. The aim of the present study …
[HTML][HTML] A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat
W Rahman, K Bannister, LA Bee, AH Dickenson - Brain research, 2011 - Elsevier
Serotonin (5-HT) plays a major yet complex role in modulating spinal nociceptive
transmission as a consequence of the number of 5-HT receptor subtypes. These include the …
transmission as a consequence of the number of 5-HT receptor subtypes. These include the …
5-Hydroxytryptamine2A/2C receptors of nucleus raphe magnus and gigantocellularis/paragigantocellularis pars α reticular nuclei modulate the unconditioned fear …
R de Oliveira, RC de Oliveira… - Behavioural Brain …, 2017 - Elsevier
The electrical stimulation of the dorsolateral columns of the periaquedutal grey matter
(dlPAG) or deep layers of the superior colliculus (dlSC) evokes defensive behaviours …
(dlPAG) or deep layers of the superior colliculus (dlSC) evokes defensive behaviours …
GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception …
M Mendonça-dos-Santos, TCT Gonçalves… - Scientific Reports, 2024 - nature.com
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5‐HT2A and 5‐HT2C serotonergic receptors in post‐ictal …
RL de Freitas, RC de Oliveira, R de Oliveira… - Synapse, 2014 - Wiley Online Library
The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5‐
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …
A PET [18F] altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation
R Kupers, VG Frokjaer, A Naert, R Christensen… - Neuroimage, 2009 - Elsevier
There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an
important role in the transmission and regulation of pain. Here we used positron emission …
important role in the transmission and regulation of pain. Here we used positron emission …
5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus
RL Freitas, CM dos Reis Ferreira, MAC Urbina… - Experimental …, 2009 - Elsevier
Pharmacological studies have been focused on the involvement of different neural pathways
in the organization of antinociception that follows tonic-clonic seizures, including 5 …
in the organization of antinociception that follows tonic-clonic seizures, including 5 …
Serotonergic neurotransmission in the dorsal raphe nucleus recruits in situ 5-HT2A/2C receptors to modulate the post-ictal antinociception
RL Freitas, GS Bassi, AM de Oliveira… - Experimental neurology, 2008 - Elsevier
The post-ictal immobility syndrome is followed by a significant increase in the nociceptive
thresholds in animals and humans. The aim of this study was to assess the involvement of …
thresholds in animals and humans. The aim of this study was to assess the involvement of …
5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal …
R da Silva Soares Jr, LL Falconi-Sobrinho… - Behavioural Brain …, 2019 - Elsevier
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory
animals evokes fear-related defensive responses, which are considered panic attack-like …
animals evokes fear-related defensive responses, which are considered panic attack-like …