The role of endoplasmic reticulum stress in regulation of intestinal barrier and inflammatory bowel disease

YR Tan, SY Shen, HQ Shen, PF Yi, BD Fu… - Experimental Cell …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic inflammatory disease involving the digestive
tract, characterized by abdominal pain, diarrhea, rectal bleeding, and so on, which can make …

[HTML][HTML] New insights into bacterial mechanisms and potential intestinal epithelial cell therapeutic targets of inflammatory bowel disease

B Liang, C Wu, C Wang, W Sun, W Chen, X Hu… - Frontiers in …, 2022 - frontiersin.org
The global incidence of inflammatory bowel disease (IBD) has increased rapidly in recent
years, but its exact etiology remains unclear. In the past decade, IBD has been reported to …

[HTML][HTML] The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation

A Carreras-Sureda, X Zhang, L Laubry, J Brunetti… - Cell Reports, 2023 - cell.com
Summary Store-operated Ca 2+ entry (SOCE) mediated by stromal interacting molecule
(STIM)-gated ORAI channels at endoplasmic reticulum (ER) and plasma membrane (PM) …

[HTML][HTML] Lycopene maintains mitochondrial homeostasis to counteract the enterotoxicity of deoxynivalenol

Z Cai, F Chen, Y Wang, X Wang, X Yang, C Zhang - Antioxidants, 2023 - mdpi.com
The intestinal tract is a target organ for Deoxynivalenol (DON) absorption and toxicity.
Mitochondrial homeostasis imbalance is the gut toxicity mechanism of DON. Lycopene …

Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease

M Letizia, YH Wang, U Kaufmann… - EMBO Molecular …, 2022 - embopress.org
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune
responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the …

Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models

L Kong, S Chen, S Huang, A Zheng, S Gao, J Ye… - Inflammation …, 2024 - Springer
Background Inflammatory bowel disease (IBD) is an increasingly prevalent global health
concern that has garnered substantial attention. However, the underlying mechanisms are …

Genetic Defects in Early-Onset Inflammatory Bowel Disease

AOB Dagci, KC Cushing - Rheumatic Disease Clinics, 2023 - rheumatic.theclinics.com
Inflammatory bowel disease (IBD) is a group of complex, multifactorial disorders
characterized by chronic inflammation of the gastrointestinal tract. The three subtypes of IBD …

[HTML][HTML] Baicalin ameliorates Mycoplasma gallisepticum-induced inflammatory injury via inhibiting STIM1-regulated ceramide accumulation in DF-1 cells

X Chen, M Ishfaq, J Wang - Poultry Science, 2023 - Elsevier
Mycoplasma gallisepticum (MG) is dependent on its host for many nutrients due to the loss
of many important metabolic pathways. Ceramide is a sphingolipid that regulates multiple …

Development and therapeutic implications of small molecular inhibitors that target calcium ion-related channels in tumor treatment

L Zhang, C Ren, J Liu, S Huang, C Wu, J Zhang - Drug Discovery Today, 2024 - Elsevier
Highlights•Calcium homeostasis is crucial in cancer, regulating many physiological
processes.•Calcium ion-related channels are crucial in cancer regulation and potential …

[HTML][HTML] Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors

AH Ghobashi, R Lanzloth, CA Ladaika, A Masood… - Cancers, 2024 - mdpi.com
Simple Summary Chronic inflammation is one of the major risk factors for colorectal cancer
development. This study aims to determine the effect of genetic mutations on inflammation …