The human proteome contains approximately 20,000 proteins, and it is estimated that more
than 600 of them are functionally important for various types of cancers, including nearly 400 …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death,
which is restricted by NPR1, an activator of systemic acquired resistance. However, the …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

Hypertension affects one billion people and is a principal reversible risk factor for
cardiovascular disease. Pseudohypoaldosteronism type II (PHAII), a rare Mendelian …

Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying
enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative …