As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …

Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A
receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5 …

Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but
often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent …

Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) 2A receptor agonists have recently emerged
as promising new treatment options for a variety of disorders. The recent success of these …

G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the
human genome (around 800 genes). They transduce signals by coupling to a small number …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …