Tuberculosis (TB) remains a prominent health concern worldwide. Besides extensive
research and vaccinations available, attempts to control the pandemic are cumbersome due …

Molecular testing is rapidly becoming an integral component of global tuberculosis (TB)
control. Uncommon mechanisms of resistance escape detection by these platforms and …

Globally, tuberculosis (TB) was the leading cause of death from a single infectious agent
until the coronavirus (COVID-19) pandemic. In 2020, an estimated 10 million people fell ill …

Tuberculosis remains the leading cause of death from a single pathogen. On the other hand,
antimicrobial resistance (AMR) makes it increasingly difficult to deal with this disease. We …

Abstract Most Mycobacterium tuberculosis (Mtb) resistant to rifampicin (RIF) has mutations in
the rpoB gene, while most Mtb resistant to isoniazid (INH) has mutations in the katG gene or …

Drug-resistant tuberculosis (DR-TB) is still a major public health concern in South Africa.
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …

Resolution advances in cryoelectron microscopy (cryo-EM) now offer the possibility to
visualize structural effects of naturally occurring resistance mutations in proteins and also of …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a tenacious
pathogen that has latently infected one third of the world's population. However …

Objective Drug-resistant tuberculosis is a major public health problem, especially in the
southern region of Xinjiang, China; however, there is little information regarding drug …

Isoniazid (INH), one of the first-line drugs used for the treatment of tuberculosis, is a prodrug
which is activated by the intracellular KatG enzyme of Mycobacterium tuberculosis. The …