Background. Head and neck squamous cell carcinoma (HNSCC) cell lines are important
preclinical models in the search for novel and targeted therapies to treat head and neck …

Background Cancer cells, including colorectal cancer ones (CRC), release high amounts of
nanovesicles (exosomes), delivering biochemical messages for paracrine or systemic …

We wished to determine the applicability of previously proposed deterministic mathematical
models to description of growth of multicellular tumour spheroids. The models were placed …

In order to determine the role of micromilieu in tumour spheroid growth, a mathematical
model was developed to predict EMT6/Ro spheroid growth and microenvironment based …

Introduction: Despite the increasing financial outlay on cancer research and drug discovery,
many advanced cancers remain incurable. One possible strategy for increasing the approval …

Cancer development can be viewed as an example of spatio-temporal pattern formation.
Several attempts have been made to model and predict malignant tumor behavior and also …

The regulation of cell growth, cell proliferation and cell death is at the basis of the
homeostasis of tissues. While they can be regulated by intrinsic and genetic factors, their …

Background Multicellular spheroids, an appropriate in vitro system for simulating 3-D tumor
micro-milieu can be used for evaluating and predicting tumor response to therapeutic agents …

We propose that a highly malignant brain tumour is an opportunistic, self‐organizing and
adaptive complex dynamic biosystem rather than an unorganized cell mass. To test the …

Pattern formation in multicellular spheroids is addressed with a hybrid lattice-gas cellular
automaton model. Multicellular spheroids serve as experimental model system for the study …