Mechanistic models are built using knowledge as the primary information source, with well-
established biological and physical laws determining the causal relationships within the …

Although commonly related to nutrient deprivation, the cause of the formation of the necrotic
core in the multicellular tumour spheroids is still a controversial issue. We propose a simple …

A penetration assay based on freeze-drying and vapour fixation was applied to show the
spatial distribution of non-bound and bound cytostatic drugs in cellular spheroids. Several …

Growing multicellular prostate tumor spheroids develop quiescent cell subpopulations in
central regions with features of intrinsic multicell‐mediated drug resistance. Doxorubicin …

Multicellular spheroids composed of transformed cells are known to mimic the growth
characteristics of tumors and to develop gradients in proliferation with increasing size. This …

Hanging drop represents a simple approach designed for the generation of 3D models that
have potential to be used for the study of solid tumors characteristics. The aim of the study …

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors
determining the prospects for its clinical use. This problem is particularly acute in the case of …

Quickly and easily producing uniform populations of microsphere-based 3D cell cultures
using droplet-based templating methods has the potential to enable widespread use of such …

We report numerical results from a 2D cellular automaton (CA) model describing the
dynamics of the in vitro cultivated multicellular spheroid obtained from EMT6/Ro (mammary …

Mammalian neural stem cells (NSC) offer great promise as therapeutic agents for the
treatment of central nervous system disorders. As a consequence of the large numbers of …