Hanging drop represents a simple approach designed for the generation of 3D models that
have potential to be used for the study of solid tumors characteristics. The aim of the study …

Quickly and easily producing uniform populations of microsphere-based 3D cell cultures
using droplet-based templating methods has the potential to enable widespread use of such …

THIS COMMENTARY is focussed on recent publications about tumour spheroid technology
in cancer therapy research and mainly on those publications describing the effects of …

Cells in the inner region of multicellular spheroids markedly reduce their oxygen
consumption rate, presumably in response to their stressful microenvironment. To determine …

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors
determining the prospects for its clinical use. This problem is particularly acute in the case of …

Multicell‐mediated drug resistance is a major impediment for the effectiveness of
chemotherapeutic approaches and has been shown to be a feature of many solid tumors …

Fluorescent dyes were used in conjunction with confocal microscopy to record the vitality
status of cells in multicellular glioma spheroids. Multicellular spheroids are in vitro models …

Background Our objective was to discover in silico axioms that are plausible representations
of the operating principles realized during characteristic growth of EMT6/Ro mouse …

To date, cell biological characteristics of oncogene‐transfected cells have been investigated
either in relatively homogeneous monolayer cultures or in heterogeneous tumors in vivo. To …

In this paper, a mathematical model based on the diffusion of nutrients is developed by
considering the physiological changes accompanying the growth of avascular tumour …