Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …

Abstract Purpose of Review Many phenotypes of asthma exist, ranging from mild asthma
with onset during childhood to severe asthma with later onset, making asthma a broad …

Sex-related differences in asthma prevalence are well established and change through the
reproductive phases of life. As children, boys have increased prevalence of asthma …

Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by
either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic …

Rationale: Asthma is a heterogeneous disease driven by diverse immunologic and
inflammatory mechanisms. Objectives: Using transcriptomic profiling of airway tissues, we …

Matricellular proteins are involved in the crosstalk between cells and their environment and
thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular …

As adults, women are twice as likely as men to have asthma; however, the mechanisms
explaining this sexual dimorphism remain unclear. Increased type 2 cytokines and/or IL-17A …

Periostin is a protein that plays a key role in development and repair within the biological
matrix of the lung. As a matricellular protein that does not contribute to extracellular matrix …

Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Noneosinophilic airway inflammation occurs in approximately 50% of patients with asthma. It
is subdivided into neutrophilic or paucigranulocytic inflammation, although the proportion of …