The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid
hormone and their structural and functional analysis revealed an evolutionarily conserved …

Objective: This review consists of three parts, representing three different possibilities of
interactions between cannabinoid receptor ligands of both exogenous and endogenous …

Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating
steroid levels and responses to half of all oxidatively metabolized drugs. CYP3A activity is …

Bile acids play an essential role in the solubilization and absorption of dietary fat and lipid-
soluble vitamins. Bile acids also modulate the transcription of various genes for enzymes …

Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …

The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as
pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) …

P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter,
functions as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in
Western countries and is considered the hepatic manifestation of metabolic syndrome. The …