Toward hydrogen sulfide based therapeutics: critical drug delivery and developability issues

Y Zheng, B Yu, LK De La Cruz… - Medicinal Research …, 2018 - Wiley Online Library
Abstract Hydrogen sulfide (H2S), together with nitric oxide (NO) and carbon monoxide (CO),
belongs to the gasotransmitter family and plays important roles in mammals as a signaling …

[HTML][HTML] Thiol reactive probes and chemosensors

H Peng, W Chen, Y Cheng, L Hakuna, R Strongin… - Sensors, 2012 - mdpi.com
Thiols are important molecules in the environment and in biological processes. Cysteine
(Cys), homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) play critical roles …

[HTML][HTML] Preventing mitochondrial reverse electron transport as a strategy for cardioprotection

HA Prag, MP Murphy, T Krieg - Basic Research in Cardiology, 2023 - Springer
In the context of myocardial infarction, the burst of superoxide generated by reverse electron
transport (RET) at complex I in mitochondria is a crucial trigger for damage during …

The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues

O Kabil, V Vitvitsky, P Xie, R Banerjee - 2011 - liebertpub.com
The enzymes of the transsulfuration pathway, cystathionine β-synthase (CBS) and
cystathionine γ-lyase (CSE), are important for the endogenous production of hydrogen …

Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Y Mikami, N Shibuya, Y Kimura, N Nagahara… - Biochemical …, 2011 - portlandpress.com
H2S (hydrogen sulfide) has recently been recognized as a signalling molecule as well as a
cytoprotectant. We recently demonstrated that 3MST (3-mercaptopyruvate sulfurtransferase) …

A near-infrared fluorescent turn-on probe for fluorescence imaging of hydrogen sulfide in living cells based on thiolysis of dinitrophenyl ether

X Cao, W Lin, K Zheng, L He - Chemical Communications, 2012 - pubs.rsc.org
A near-infrared fluorescent turn-on probe for fluorescence imaging of hydrogen sulfide in living
cells based on thiolysis of dinitrophenyl ether - Chemical Communications (RSC Publishing) …

The emerging role of irisin in cardiovascular diseases

J Fu, F Li, Y Tang, L Cai, C Zeng, Y Yang… - Journal of the American …, 2021 - Am Heart Assoc
Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease
from a membrane‐spanning protein, FNDC5 (fibronectin type III domain‐containing protein …

Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation—a tale of three gases!

L Li, A Hsu, PK Moore - Pharmacology & therapeutics, 2009 - Elsevier
Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S) together make up a
family of biologically active gases (the so-called 'gaseous triumvirate') with an increasingly …

Hydrogen sulfide in the mammalian cardiovascular system

YH Liu, M Lu, LF Hu, PTH Wong… - Antioxidants & redox …, 2012 - liebertpub.com
For more than a century, hydrogen sulfide (H2S) has been regarded as a toxic gas. This
review surveys the growing recognition of the role of H2S as an endogenous signaling …

Reactive sulfur species: a new redox player in cardiovascular pathophysiology

GK Kolluru, X Shen, CG Kevil - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator
of critical biological processes. However, the physiological significance of hydrogen sulfide …