Microtubules play an important role in the process of cell mitosis and can form a spindle in
the mitotic prophase of the cell, which can pull chromosomes to the ends of the cell and then …

Developing efficient cancer treatment modalities is crucial, given the tens of thousands of
deaths that cancer causes each year. Although there are various treatment modalities …

Photodynamic therapy (PDT) is a minimally invasive combination of treatments that treat
tumors and other diseases by using photosensitizers, light and oxygen to produce cytotoxic …

Despite the significant progress in anticancer drug development over recent years, there is a
vital need for newer agents with unique, but still effective, mechanisms of action in order to …

Since their use during the First World War, Blister agents have posed a major threat to the
individuals and have caused around two million casualties. Major incidents occurred not …

DNA adducting drugs, including alkylating agents and platinum-containing drugs, are
prominent in cancer chemotherapy. Their mechanisms of action involve direct interaction …

Aims Overproduction of reactive oxygen species (ROS) is a pathologic hallmark of
cyclophosphamide toxicity. For this reason, antioxidant compounds emerge as promising …

DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The
establishment of predictive biomarkers to identify patients who will effectively respond to …

Nitrogen mustard (NM) is a cytotoxic vesicant known to cause pulmonary injury that can
progress to fibrosis. NM toxicity is associated with an influx of inflammatory macrophages in …

Chemotherapy constitutes the backbone of cancer treatment. Several predictive assays
assist personalized administration of cytotoxic drugs and are recommended for use in a …