Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes
ion channels located at the tips of the bundle to open, thereby initiating the perception of …

Recent advances in human genomics led to the identification of numerous defective genes
causing deafness, which represent novel putative therapeutic targets. Future gene-based …

When hearing fails, cochlear implants (CIs) provide open speech perception to most of the
currently half a million CI users. CIs bypass the defective sensory organ and stimulate the …

A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in
people with severe sensorineural hearing loss (SNHL). However, these neurons …

US7479554B2 - AAV5 nucleic acids - Google Patents US7479554B2 - AAV5 nucleic acids -
Google Patents AAV5 nucleic acids Download PDF Info Publication number US7479554B2 …

US8283151B2 - Isolation, cloning and characterization of new adeno-associated virus (AAV)
serotypes - Google Patents US8283151B2 - Isolation, cloning and characterization of new …

Localization of mechanotransduction in sensory hair cells to hair bundles requires selective
targeting of essential proteins to specific locations. Isoform 2 of the plasma-membrane Ca2+ …

Gene transfer into the cells of the cochlea is useful for both research and therapy. Bovine
adeno-associated virus (BAAV) is a new viral vector with potential for long-term gene …

Mechanosensation, the transduction of mechanical force into electrochemical signals,
allows organisms to detect touch and sound, to register movement and gravity, and to sense …

Sensory hair cells of the inner ear express multiple physiologically defined conductances,
including mechanotransduction, Ca 2+, Na+, and several distinct K+ conductances, all of …