Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

Volume electron microscopy is the method of choice for the in situ interrogation of cellular
ultrastructure at the nanometer scale, and with the increase in large raw image datasets …

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …

Introduction The tight structure of the blood–brain barrier severely limits the level of drug
therapy for central nervous system disorders. In this study, a novel composite delivery …

In the past 20 years, PCSK9 has been shown to play a pivotal role in LDL cholesterol
metabolism and cardiovascular health by inducing the lysosomal degradation of the LDL …

Chronic and neuropathic pain are a widespread burden. Incomplete understanding of
underlying pathomechanisms is one crucial factor for insufficient treatment. Recently …

The highly specialized nonmyelinating glial cells present at somatic peripheral nerve
endings, known collectively as terminal Schwann cells (TSCs), play critical roles in the …

In dorsal root ganglia (DRG), macrophages reside in close proximity to sensory neurons,
and their functions have largely been explored in the context of pain, nerve injury and repair …

Background Blood nerve barrier (BNB) participates in the development of neuropathic pain.
AQP1 is involved in peripheral pain perception and is negatively correlated with HIF-1α …

Oxaliplatin, a platinum-based anticancer drug, is associated with peripheral neuropathy
(oxaliplatin-induced peripheral neuropathy, OIPN), which can lead to worsening of quality of …