Genetic insights into the neurodevelopmental origins of schizophrenia

R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water - Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

MJ Gandal, P Zhang, E Hadjimichael, RL Walker… - Science, 2018 - science.org
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

What genes are differentially expressed in individuals with schizophrenia? A systematic review

AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

Pleiotropy and cross-disorder genetics among psychiatric disorders

PH Lee, YCA Feng, JW Smoller - Biological psychiatry, 2021 - Elsevier
Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Recent advances in the genetics of schizophrenia

D Avramopoulos - Complex Psychiatry, 2018 - karger.com
The last decade brought tremendous progress in the field of schizophrenia genetics. As a
result of extensive collaborations and multiple technological advances, we now recognize …

Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder

J Guan, JJ Cai, G Ji, PC Sham - Translational psychiatry, 2019 - nature.com
Individuals affected with different neuropsychiatric disorders such as autism (AUT),
schizophrenia (SCZ) and bipolar disorder (BPD), may share similar clinical manifestations …

Decreased brain pH as a shared endophenotype of psychiatric disorders

H Hagihara, VS Catts, Y Katayama, H Shoji… - …, 2018 - nature.com
Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased
brain pH relative to those of healthy controls upon postmortem examination, it remains …

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

S Bandres‐Ciga, S Saez‐Atienzar… - Movement …, 2019 - Wiley Online Library
Background PD is a complex polygenic disorder. In recent years, several genes from the
endocytic membrane‐trafficking pathway have been suggested to contribute to disease …

The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond

PM Zakutansky, Y Feng - Cells, 2022 - mdpi.com
Neuropsychiatric diseases are among the most common brain developmental disorders,
represented by schizophrenia (SZ). The complex multifactorial etiology of SZ remains poorly …