Osteosarcoma is the most common primary malignant tumour of the bone. Osteosarcoma
incidence is bimodal, peaking at 18 and 60 years of age, and is slightly more common in …

Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Osteosarcoma occurs in children and adolescents frequently and leads to a high fatality rate.
Although surgical resection is the most common methods in clinic, patients always suffer …

The complex physiological environment in bone tissue poses a challenge to the efficient
delivery of chemotherapeutic agents for osteosarcoma (OS) treatment; hence, an efficient …

Chemotherapy elicits tumor immune evasion with poorly characterized mechanisms. Here,
we demonstrate that chemotherapy markedly enhances the expression levels of CD47 in …

Phenolic compounds are natural phytochemicals that have recently reported numerous
health benefits. Resveratrol, curcumin, and quercetin have recently received the most …

Targeted delivery by either systemic or local targeting of therapeutics to the bone is an
attractive treatment for various bone metabolism diseases such as osteoporosis …

Osteosarcoma (OS) is a highly malignant tumor occurring in bone tissue with a high
propensity to metastasize, and its underlying mechanisms remain largely elusive. The OS …

MicroRNAs (miRNAs) are a widely-studied class of non-coding RNAs characterized by their
short length (18-25 nucleotides). The precise functions of miRNAs are not well-elucidated; …