Podocytopathies
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …
Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
[HTML][HTML] Podocyte injury and its consequences
M Nagata - Kidney international, 2016 - Elsevier
Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …
on their highly differentiated postmitotic phenotype, which also defines the particular …
Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome
WY Ding, V Kuzmuk, S Hunter, A Lay… - Science Translational …, 2023 - science.org
Gene therapy for kidney diseases has proven challenging. Adeno-associated virus (AAV) is
used as a vector for gene therapy targeting other organs, with particular success …
used as a vector for gene therapy targeting other organs, with particular success …
The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction
RL Chevalier - American Journal of Physiology-Renal …, 2016 - journals.physiology.org
There is an alarming global increase in the incidence of end-stage kidney disease, for which
early biomarkers and effective treatment options are lacking. Largely based on the histology …
early biomarkers and effective treatment options are lacking. Largely based on the histology …
Focal segmental glomerulosclerosis
VD D'Agati, FJ Kaskel, RJ Falk - New England Journal of …, 2011 - Mass Medical Soc
Focal segmental glomerulosclerosis, which is characterized by progressive glomerular
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …
Differentiated kidney epithelial cells repair injured proximal tubule
Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …
Relevance of oxygen concentration in stem cell culture for regenerative medicine
C Mas-Bargues, J Sanz-Ros… - International journal of …, 2019 - mdpi.com
The key hallmark of stem cells is their ability to self-renew while keeping a differentiation
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …
potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell …
[HTML][HTML] The ageing kidney: Molecular mechanisms and clinical implications
Y Fang, AY Gong, ST Haller, LD Dworkin, Z Liu… - Ageing research …, 2020 - Elsevier
As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …
challenge for clinical practices. Human ageing is associated with molecular, structural, and …