Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial
diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency …

Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade.
Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly …

Epstein–Barr virus positivity (EBV (+)) and high‐microsatellite instability (MSI‐H) have been
identified as molecular subgroups in gastric carcinoma. The aim of our study was to …

Purpose: Colorectal cancers with microsatellite instability–high (MSI-H) status, due to
mismatch repair deficiency, are associated with poor patient outcomes after relapse. We …

Introduction For the past two decades, microsatellite instability (MSI) has been reported as a
robust clinical biomarker associated with survival advantage attributed to its immunogenicity …

Background Microsatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC).
The biological significance of MSI‐low (MSI‐L) phenotype and its differences with …

BACKGROUND Approximately 40% of colorectal cancer (CRC) cases are linked to Kirsten
rat sarcoma viral oncogene homolog (KRAS) mutations. KRAS mutations are associated …

Background The aim of this study was to clarify clinicopathological features, frequencies of
molecular biomarkers, and prognoses in Japanese colorectal cancer patients and compare …

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA
mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest …

Mismatch repair deficiency (dMMR) predicts response to immune checkpoint inhibitor
therapy in solid tumors. Long mononucleotide repeat (LMR) markers may improve the …