The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …

Randomized controlled trials (RCTs) form a cornerstone of oncology research by generating
evidence about the efficacy of therapies in selected patient populations. However, their …

Abstract The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer. sanger.
ac. uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in …

Summary We analyzed 2,532 lung adenocarcinomas (LUAD) to identify the
clinicopathological and genomic features associated with metastasis, metastatic burden …

Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal
survival outcomes. A major barrier in the field has been the relative paucity of human tumors …

PURPOSE To determine the genetic predisposition underlying pancreatic acinar cell
carcinoma (PACC) and characterize its genomic features. METHODS Both somatic and …

Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …

Molecular features underlying colorectal cancer disparities remain uncharacterized. Here,
we investigated somatic mutation patterns by race/ethnicity and sex among 5,856 non …

Background Homologous recombination repair mutation (HRRm) status may guide risk-
stratification and treatment decisions, including polyadenosine diphosphate–ribose …

The mitogen-activated protein kinase (MAPK) pathway is essential for cellular proliferation,
growth, and survival. Constitutive activation of this pathway by BRAF mutations can cause …