[HTML][HTML] From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H2O2 and targeting nanotherapeutics

M Shao, Y Wang, H Dong, L Wang, X Zhang, X Han… - Bioactive Materials, 2023 - Elsevier
Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays.
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …

Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles

Y Li, R Liu, M Ding, Q Zheng, J Wu, X Xue… - Acta Pharmacologica …, 2022 - nature.com
Liver fibrosis is the common consequence of almost all liver diseases and has become an
urgent clinical problem without efficient therapies. Recent evidence has shown that …

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

X Guo, W Lin, W Wen, J Huyghe, S Bien, Q Cai… - Gastroenterology, 2021 - Elsevier
Background And Aims Susceptibility genes and the underlying mechanisms for the majority
of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer …

Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease

YR Shim, WI Jeong - Experimental & Molecular Medicine, 2020 - nature.com
Alcoholic liver disease (ALD) is one of the fastest-growing concerns worldwide. In addition to
bacterial endotoxins in the portal circulation, recent lines of evidence have suggested that …

Oxidative stress—a key player in the course of alcohol-related liver disease

A Michalak, T Lach, H Cichoż-Lach - Journal of clinical medicine, 2021 - mdpi.com
Oxidative stress is known to be an inseparable factor involved in the presentation of liver
disorders. Free radicals interfere with DNA, proteins, and lipids, which are crucial in liver …

[HTML][HTML] Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment

Z Ma, X Xue, J Bai, Y Cai, X Jin, K Jia, M Ding… - Biomedicine & …, 2022 - Elsevier
Abstract Si-Wu-Tang (SWT), a traditional Chinese medicine formula firstly recorded from the
Tang dynasty, has been reported to alleviate gynecological and liver diseases. We …

[HTML][HTML] Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases

YS Kim, SG Kim - Clinical and Molecular Hepatology, 2020 - ncbi.nlm.nih.gov
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in
hepatocytes as the earliest response. Both liver diseases share common disease features …

Alcoholic liver disease: a new insight into the pathogenesis of liver disease

SH Park, YS Lee, J Sim, S Seo, W Seo - Archives of Pharmacal Research, 2022 - Springer
Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases,
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition

P Yao, Z Zhang, H Liu, P Jiang, W Li, W Du - The EMBO Journal, 2023 - embopress.org
The tumor suppressor p53 is critical for tumor suppression, but the regulatory role of p53 in
alcohol‐induced fatty liver remains unclear. Here, we show a role for p53 in regulating …

[HTML][HTML] Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα …

J Ma, H Cao, RM Rodrigues, M Xu, T Ren, Y He… - JCI insight, 2020 - ncbi.nlm.nih.gov
Alcohol-associated liver disease is a spectrum of liver disorders with histopathological
changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular …