[HTML][HTML] From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H2O2 and targeting nanotherapeutics
M Shao, Y Wang, H Dong, L Wang, X Zhang, X Han… - Bioactive Materials, 2023 - Elsevier
Liver fibrosis and hepatocellular carcinoma (HCC) have been worldwide threats nowadays.
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …
Liver fibrosis is reversible in early stages but will develop precancerosis of HCC in cirrhotic …
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles
Y Li, R Liu, M Ding, Q Zheng, J Wu, X Xue… - Acta Pharmacologica …, 2022 - nature.com
Liver fibrosis is the common consequence of almost all liver diseases and has become an
urgent clinical problem without efficient therapies. Recent evidence has shown that …
urgent clinical problem without efficient therapies. Recent evidence has shown that …
Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects
Background And Aims Susceptibility genes and the underlying mechanisms for the majority
of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer …
of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer …
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
YR Shim, WI Jeong - Experimental & Molecular Medicine, 2020 - nature.com
Alcoholic liver disease (ALD) is one of the fastest-growing concerns worldwide. In addition to
bacterial endotoxins in the portal circulation, recent lines of evidence have suggested that …
bacterial endotoxins in the portal circulation, recent lines of evidence have suggested that …
Oxidative stress—a key player in the course of alcohol-related liver disease
A Michalak, T Lach, H Cichoż-Lach - Journal of clinical medicine, 2021 - mdpi.com
Oxidative stress is known to be an inseparable factor involved in the presentation of liver
disorders. Free radicals interfere with DNA, proteins, and lipids, which are crucial in liver …
disorders. Free radicals interfere with DNA, proteins, and lipids, which are crucial in liver …
[HTML][HTML] Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment
Z Ma, X Xue, J Bai, Y Cai, X Jin, K Jia, M Ding… - Biomedicine & …, 2022 - Elsevier
Abstract Si-Wu-Tang (SWT), a traditional Chinese medicine formula firstly recorded from the
Tang dynasty, has been reported to alleviate gynecological and liver diseases. We …
Tang dynasty, has been reported to alleviate gynecological and liver diseases. We …
[HTML][HTML] Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases
YS Kim, SG Kim - Clinical and Molecular Hepatology, 2020 - ncbi.nlm.nih.gov
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in
hepatocytes as the earliest response. Both liver diseases share common disease features …
hepatocytes as the earliest response. Both liver diseases share common disease features …
Alcoholic liver disease: a new insight into the pathogenesis of liver disease
Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases,
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …
p53 protects against alcoholic fatty liver disease via ALDH2 inhibition
The tumor suppressor p53 is critical for tumor suppression, but the regulatory role of p53 in
alcohol‐induced fatty liver remains unclear. Here, we show a role for p53 in regulating …
alcohol‐induced fatty liver remains unclear. Here, we show a role for p53 in regulating …
[HTML][HTML] Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα …
Alcohol-associated liver disease is a spectrum of liver disorders with histopathological
changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular …
changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular …