There is a significant inverse relationship between intragastric acidity and plasma gastrin
concentration. All generally available gastric acid antisecretory drugs induce a release of …

Peptic ulcers are believed to develop because of increased acid and pepsin secretion, a
reduced mucosal defense mechanism, or a combination of these two abnormalities …

We investigated in dogs the effect of graded frequencies of electrical vagal stimulation (1.5,
3, 6, and 12 cps) on pancreatic exocrine secretion and on portal blood levels of gastrin …

To examine the role of gastrin as a major mediator of meal-stimulated acid secretion at low
and high intragastric pH, gastric acid secretory responses after exogenous and endogenous …

H. pylori infection is associated with acid-peptic disease, although its role in the
pathogenesis is unclear. The purpose of this study was to determine if chronic infection in …

Background A gastrin receptor antagonist, CR2194 (spiroglumide), was used to explore the
physiological role of gastrin in regulating gastric acid secretion in humans. Materials and …

The effect of synthetic human gastrin I, infused at two doses, on the concentrations of
somatostatin, pancreatic polypeptide, and vasoactive intestinal peptide in portal and …

Most discussions about the aetiology of duodenal ulcer depict the duodenal bulb as a
battlefield, on which aggressive and defensive factors wage a continuous and continuing …

Objective: In healthy subjects a gastric meal at low pH inhibits gastric acid secretion,
possibly by reducing gastrin release, whereas duodenal ulcer (DU) patients have been …

Newborn dogs, humans, and rats have elevated gastric luminal pH values and significantly
elevated serum gastrin levels compared to adults. In the adult, acidification of the antral …