Natural killer cell specificity for viral infections
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
Biology of natural killer cells
G Trinchieri - Advances in immunology, 1989 - Elsevier
Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …
[HTML][HTML] The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
VAK Rathinam, Z Jiang, SN Waggoner, S Sharma… - Nature …, 2010 - nature.com
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-
1β) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating …
1β) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating …
[HTML][HTML] Natural killer cells act as rheostats modulating antiviral T cells
Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human
immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or …
immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or …
Natural killer cells in antiviral defense: function and regulation by innate cytokines
CA Biron, KB Nguyen, GC Pien… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …
Noncytolytic control of viral infections by the innate and adaptive immuneresponse
LG Guidotti, FV Chisari - Annual review of immunology, 2001 - annualreviews.org
This review describes the contribution of noncytolytic mechanisms to the control of viral
infections with a particular emphasis on the role of cytokines in these processes. It has long …
infections with a particular emphasis on the role of cytokines in these processes. It has long …
Viral subversion of the immune system
D Tortorella, BE Gewurz, MH Furman… - Annual review of …, 2000 - annualreviews.org
This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …
viruses to elude immune detection and destruction. These include targeting of pathways for …
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by …
JS Orange, B Wang, C Terhorst, CA Biron - The Journal of experimental …, 1995 - rupress.org
The presence of natural killer (NK) cells contributes to early defense against murine
cytomegalovirus (MCMV) infection. Although NK cells can mediate in vivo protection against …
cytomegalovirus (MCMV) infection. Although NK cells can mediate in vivo protection against …
Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H
KA Daniels, G Devora, WC Lai, CL O'Donnell… - The Journal of …, 2001 - rupress.org
Antiviral roles of natural killer (NK) cell subsets were examined in C57BL/6 mice infected
with murine cytomegalovirus (MCMV) and other viruses, including lymphocytic …
with murine cytomegalovirus (MCMV) and other viruses, including lymphocytic …
Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs
MJ Reddehase, F Weiland, K Münch, S Jonjic… - Journal of …, 1985 - Am Soc Microbiol
Interstitial pneumonia associated with viral replication in lung tissue was observed after
cytomegalovirus infection of total-body gamma-irradiated mice, whereas in …
cytomegalovirus infection of total-body gamma-irradiated mice, whereas in …