Natural killer cell specificity for viral infections

Q Hammer, T Rückert, C Romagnani - Nature immunology, 2018 - nature.com
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …

Biology of natural killer cells

G Trinchieri - Advances in immunology, 1989 - Elsevier
Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

[HTML][HTML] The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

VAK Rathinam, Z Jiang, SN Waggoner, S Sharma… - Nature …, 2010 - nature.com
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-
1β) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating …

[HTML][HTML] Natural killer cells act as rheostats modulating antiviral T cells

SN Waggoner, M Cornberg, LK Selin, RM Welsh - Nature, 2012 - nature.com
Antiviral T cells are thought to regulate whether hepatitis C virus (HCV) and human
immunodeficiency virus (HIV) infections result in viral control, asymptomatic persistence or …

Natural killer cells in antiviral defense: function and regulation by innate cytokines

CA Biron, KB Nguyen, GC Pien… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …

Noncytolytic control of viral infections by the innate and adaptive immuneresponse

LG Guidotti, FV Chisari - Annual review of immunology, 2001 - annualreviews.org
This review describes the contribution of noncytolytic mechanisms to the control of viral
infections with a particular emphasis on the role of cytokines in these processes. It has long …

Viral subversion of the immune system

D Tortorella, BE Gewurz, MH Furman… - Annual review of …, 2000 - annualreviews.org
This review describes the diverse array of pathways and molecular targets that are used by
viruses to elude immune detection and destruction. These include targeting of pathways for …

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by …

JS Orange, B Wang, C Terhorst, CA Biron - The Journal of experimental …, 1995 - rupress.org
The presence of natural killer (NK) cells contributes to early defense against murine
cytomegalovirus (MCMV) infection. Although NK cells can mediate in vivo protection against …

Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H

KA Daniels, G Devora, WC Lai, CL O'Donnell… - The Journal of …, 2001 - rupress.org
Antiviral roles of natural killer (NK) cell subsets were examined in C57BL/6 mice infected
with murine cytomegalovirus (MCMV) and other viruses, including lymphocytic …

Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs

MJ Reddehase, F Weiland, K Münch, S Jonjic… - Journal of …, 1985 - Am Soc Microbiol
Interstitial pneumonia associated with viral replication in lung tissue was observed after
cytomegalovirus infection of total-body gamma-irradiated mice, whereas in …