The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Cancer cells acquire distinct metabolic preferences based on their tissue of origin, genetic
alterations and degree of interaction with systemic hormones and metabolites. These …

Objective N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase
METTL3 are involved in tumour initiation and progression via the regulation of RNA function …

Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients
for tumorigenesis and development. These redirected metabolic pathways associated with …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …