p53 and tumor suppression: it takes a network
AM Boutelle, LD Attardi - Trends in cell biology, 2021 - cell.com
The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53
suppresses tumorigenesis by transcriptionally regulating a network of target genes that play …
suppresses tumorigenesis by transcriptionally regulating a network of target genes that play …
Prevention and early detection of prostate cancer
Prostate cancer is a common malignancy in men and the worldwide burden of this disease
is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control …
is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control …
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients
respond well to therapy, others do not, and thus more precise, individualized treatment …
respond well to therapy, others do not, and thus more precise, individualized treatment …
Tracking the clonal origin of lethal prostate cancer
MC Haffner, T Mosbruger, DM Esopi… - The Journal of …, 2013 - Am Soc Clin Investig
Recent controversies surrounding prostate cancer overtreatment emphasize the critical
need to delineate the molecular features associated with progression to lethal metastatic …
need to delineate the molecular features associated with progression to lethal metastatic …
Copy number alteration burden predicts prostate cancer relapse
H Hieronymus, N Schultz, A Gopalan… - Proceedings of the …, 2014 - National Acad Sciences
Primary prostate cancer is the most common malignancy in men but has highly variable
outcomes, highlighting the need for biomarkers to determine which patients can be …
outcomes, highlighting the need for biomarkers to determine which patients can be …
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study
Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
A Sehrawat, L Gao, Y Wang… - Proceedings of the …, 2018 - National Acad Sciences
Medical castration that interferes with androgen receptor (AR) function is the principal
treatment for advanced prostate cancer. However, clinical progression is universal, and …
treatment for advanced prostate cancer. However, clinical progression is universal, and …
Pathway-based personalized analysis of cancer
We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor
sample on the basis of expression data. This score is determined, in a context-specific …
sample on the basis of expression data. This score is determined, in a context-specific …
Hexokinase 2-mediated Warburg effect is required for PTEN-and p53-deficiency-driven prostate cancer growth
L Wang, H Xiong, F Wu, Y Zhang, J Wang, L Zhao… - Cell reports, 2014 - cell.com
Accumulating evidence suggests that codeletion of the tumor suppressor genes Pten and
p53 plays a crucial role in the development of castration-resistant prostate cancer in vivo …
p53 plays a crucial role in the development of castration-resistant prostate cancer in vivo …
Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity
ZA Wang, A Mitrofanova, SK Bergren… - Nature cell …, 2013 - nature.com
A key issue in cancer biology is whether oncogenic transformation of different cell types of
origin within an adult tissue gives rise to distinct tumour subtypes that differ in their prognosis …
origin within an adult tissue gives rise to distinct tumour subtypes that differ in their prognosis …