A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer
Molecular analysis of patient tissue samples is essential to characterize the in vivo variability
in human cancers which are not accessible in cell-lines or animal models. This applies …
in human cancers which are not accessible in cell-lines or animal models. This applies …
Molecular classification of prostate adenocarcinoma by the integrated somatic mutation profiles and molecular network
Prostate cancer is one of the most common cancers in men and a leading cause of cancer
death worldwide, displaying a broad range of heterogeneity in terms of clinical and …
death worldwide, displaying a broad range of heterogeneity in terms of clinical and …
Overexpression of the chromatin remodeler death-domain–associated protein in prostate cancer is an independent predictor of early prostate-specific antigen …
MC Tsourlakis, M Schoop, C Plass, H Huland… - Human pathology, 2013 - Elsevier
Molecular markers reliably predicting the aggressiveness of prostate cancer are currently
lacking. Death-domain–associated protein (DAXX) has been implicated in the regulation of …
lacking. Death-domain–associated protein (DAXX) has been implicated in the regulation of …
Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors
Heterogeneity of cancer means many tumorigenic genes are only aberrantly expressed in a
subset of patients and thus follow a bimodal distribution, having two modes of expression …
subset of patients and thus follow a bimodal distribution, having two modes of expression …
A new texture and shape based technique for improving meningioma classification
Over the past decade, computer‐aided diagnosis is rapidly growing due to the availability of
patient data, sophisticated image acquisition tools and advancement in image processing …
patient data, sophisticated image acquisition tools and advancement in image processing …
SEPA: signaling entropy-based algorithm to evaluate personalized pathway activation for survival analysis on pan-cancer data
Motivation Biomarkers with prognostic ability and biological interpretability can be used to
support decision-making in the survival analysis. Genes usually form functional modules to …
support decision-making in the survival analysis. Genes usually form functional modules to …
Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse and links inflammatory chemokine expression to aberrant …
S Krossa, MK Andersen, E Midtbust, M Wess, A Kiviaho… - bioRxiv, 2024 - biorxiv.org
Understanding the molecular characteristics and changes of the tumor microenvironment
(TME) associated with aggressive prostate cancer (PCa) is essential for precise diagnosis …
(TME) associated with aggressive prostate cancer (PCa) is essential for precise diagnosis …
[HTML][HTML] Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids
K Unno, M Roh, YA Yoo, Y Al-Shraideh, L Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Genomic studies are rapidly identifying genetic alterations in human cancer, but functional
validation of such alterations has been slow. Here, using human prostate cancer as a model …
validation of such alterations has been slow. Here, using human prostate cancer as a model …
[HTML][HTML] Machine learning estimated probability of relapse in early-stage non-small-cell lung cancer patients with aneuploidy imputation scores and knowledge graph …
Motivation: Low-stage lung cancer is known to recur unpredictably, and patients receiving
various treatment methods like radiation, chemotherapy, and immunotherapies have been …
various treatment methods like radiation, chemotherapy, and immunotherapies have been …
Distance in cancer gene expression from stem cells predicts patient survival
The degree of histologic cellular differentiation of a cancer has been associated with
prognosis but is subjectively assessed. We hypothesized that information about tumor …
prognosis but is subjectively assessed. We hypothesized that information about tumor …