Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

DNA methylation refers to the addition of a methyl group to nucleotides within DNA. As with
other epigenetic endpoints, patterns of DNA methylation are susceptible to alterations due to …

Bisphenol A (BPA) is an abundant environmental contaminant and studies have shown the
presence of BPA in the urine of over 90% of population tested in Canada and USA. In …

Post-fertilization epigenome reprogramming erases epigenetic marks transmitted through
gametes and establishes new marks during mid-blastula stages. The mouse embryo …

1. Introduction 2. Molecular Regulation of the Hypothalamic–Pituitary–Interrenal (HPI) Axis
2.1. Hypothalamus 2.2. Pituitary 2.3. Head Kidney (Interrenal Tissue) 3. Genomic Cortisol …

The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …

It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …

This study was conducted to investigate the effects of embryonic short-term exposure to
benzo (a) pyrene (BaP), a model polycyclic aromatic hydrocarbon, on ovarian development …

Transition from pluripotency to differentiation is a pivotal yet poorly understood
developmental step. Here, we show that the tumour suppressor RASSF1A is a key player …

Abstract Benzo [a] pyrene (BaP) is an established carcinogen and reproductive and
developmental toxicant. BaP exposure in humans and animals has been linked to infertility …